Silica nanoparticles modified with aminosilanes as carriers for plasmid DNA
C Kneuer, M Sameti, EG Haltner, T Schiestel… - International journal of …, 2000 - Elsevier
We synthesised silica nanoparticles (SiNP) with covalently linked cationic surface
modifications and demonstrated their ability to electrostatically bind, condense and protect
plasmid DNA. These particles might be utilised as DNA carriers for gene delivery. All
nanoparticles were sized between 10 and 100 nm and displayed surface charge potentials
from+ 7 to+ 31mV at pH 7.4. They were produced by modification of commercially available
(IPAST) or in-house synthesised silica particles with either N-(2-aminoethyl)-3 …
modifications and demonstrated their ability to electrostatically bind, condense and protect
plasmid DNA. These particles might be utilised as DNA carriers for gene delivery. All
nanoparticles were sized between 10 and 100 nm and displayed surface charge potentials
from+ 7 to+ 31mV at pH 7.4. They were produced by modification of commercially available
(IPAST) or in-house synthesised silica particles with either N-(2-aminoethyl)-3 …
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